1986年毕业于南开大学生物系生物化学专业，1989年获得南开大学生物化学硕士学位，2012年获得天津大学生物医学工程博士学位。
现为中国抗癌协会肿瘤标志物专业委员会委员、中国抗癌协会分子医学专业委员会委员、天津市生物化学与分子生物学学会理事、天津市生物医学工程学会组织工程专业委员会委员，科技部重大专项和国家自然科学基金项目评审专家，《中国肿瘤临床》执行编委、《中华肿瘤防治杂志》和《现代仪器与医疗》杂志编委。
研究方向：
近年来主持的研究项目：
近年发表SCI论文(*通讯作者)：
1.ZhaoY,MaJ,FanY,WangZ,TianR,JiW,ZhangF*,NiuR*:TGF-betatransactivatesEGFRandfacilitatesbreastcancermigrationandinvasionthroughcanonicalSmad3andERK/Sp1signalingpathways.Molecularoncology2018,12(3):305-321.
2.YuanJ,YangY,GaoZ,WangZ,JiW,SongW,ZhangF*,NiuR*:Tyr23phosphorylationofAnxa2enhancesSTAT3activationandpromotesproliferationandinvasionofbreastcancercells.BreastCancerResTreat2017,164(2):327-340.
3.SunX,ZhangJ,WangZ,JiW,TianR,ZhangF*,NiuR*:Shp2PlaysaCriticalRoleinIL-6-InducedEMTinBreastCancerCells.Internationaljournalofmolecularsciences2017,18(2).
4.YangY,WuN,WangZ,ZhangF,TianR,JiW,RenX,NiuR*:Rack1MediatestheInteractionofP-GlycoproteinwithAnxa2andRegulatesMigrationandInvasionofMultidrug-ResistantBreastCancerCells.Internationaljournalofmolecularsciences2016,17(10).
5.ZhangJ,ZhangF,NiuR*:FunctionsofShp2incancer.JCellMolMed2015,19(9):2075-2083.
6.ZhangF,WangZ,YuanJ,WeiX,TianR,NiuR*:RNAi-mediatedsilencingofAnxa2inhibitsbreastcancercellproliferationbydownregulatingcyclinD1inSTAT3-dependentpathway.BreastCancerResTreat2015,153(2):263-275.
7.ZhangF,WangZ,FanY,XuQ,JiW,TianR,NiuR*:ElevatedSTAT3Signaling-MediatedUpregulationofMMP-2/9ConfersEnhancedInvasionAbilityinMultidrug-ResistantBreastCancerCells.Internationaljournalofmolecularsciences2015,16(10):24772-24790.
8.ZhangF,LiuY,WangZ,SunX,YuanJ,WangT,TianR,JiW,YuM,ZhaoY,NiuR*:AnovelAnxa2-interactingproteinEbp1inhibitscancerproliferationandinvasionbysuppressingAnxa2proteinlevel.MolCellEndocrinol2015,411:75-85.
9.ZhangF,ZhangH,WangZ,YuM,TianR,JiW,YangY,NiuR*:P-glycoproteinassociateswithAnxa2andpromotesinvasioninmultidrugresistantbreastcancercells.BiochemPharmacol2014,87(2):292-302.
10.WuB,ZhangF,YuM,ZhaoP,JiW,ZhangH,HanJ,NiuR*:Up-regulationofAnxa2genepromotesproliferationandinvasionofbreastcancerMCF-7cells.Cellproliferation2012,45(3):189-198.
11.WangH,WangS,LiaoZ,ZhaoP,SuW,NiuR*,ChangJ:Folate-targetingmagneticcore-shellnanocarriersforselectivedrugreleaseandimaging.Internationaljournalofpharmaceutics2012,430(1-2):342-349.
12.HanJ,ZhangF,YuM,ZhaoP,JiW,ZhangH,WuB,WangY,NiuR*:RNAinterference-mediatedsilencingofNANOGreducescellproliferationandinducesG0/G1cellcyclearrestinbreastcancercells.CancerLett2012,321(1):80-88.
博士生导师：李祥春
公共实验室
研究员，教授，博士生导师
2016年毕业于香港中文大学，生物信息学方向，长期从事肿瘤基因组二代测序数据分析和挖掘工作的研究，对肿瘤基因组学前沿研究方法和思路有深刻理解。熟练掌握肿瘤基因分析技术方法：数据比对、突变检测、结构变异分析、肿瘤异质性分析、突变特征图谱分析、驱动基因筛选、分子分型和标记物筛选和新抗原分析等。近5年来在国际权威刊物（Nature、Gut、PNAS、NatureCommunications、CancerResearch和MolecularBiologyandEvolution等）上以第一作者身份共发表SCI论文8篇，截止到目前为止一共发表近20篇SCI论文。
近5年发表SCI论文：
1.XiangchunLi,MYWang,MengYang,HongjiDai,BaifengZhang,WeiWang,XinleiChu,XinWang,HongZheng,RuifangNiu,KexinChen.Amutationalsignatureassociatedwithalcoholconsumptionandprognosticallysignificantlymutateddrivergenesinesophagealsquamouscellcarcinoma.AnnalsofOncology.2018Jan16.(IF:11.855)
2.WilliamK.K.Wu,XiangchunLi,XiansongWang,RudinZ.W.Dai,AlfredS.L.Cheng,MaggieH.T.Wang,ThomasKwong,TaiC.Chow,JunYu,MatthewT.V.Chan,S.H.W.Oncogeneswithoutaneighboringtumor-suppressorgenearemorepronetoamplification.MolBiolEvol.(2017).doi:10.1093(IF:13)
3.Li,Xiangchun,Wu,W.K.K.,Xing,R.,Wong,S.H.,&Liu,Y.(2016).Distinctsubtypesofgastriccancerdefinedbymolecularcharacterizationincludenovelmutationalsignatureswithprognosticcapability,CancerResearch,76(7),1724–1733.doi:10.1158/0008-5472.CAN-15-2443(IF:9.329)
4.Nakatsu,G.,Li,Xiangchun,Zhou,H.,Sheng,J.,Wong,S.H.,Wu,W.K.K.,...Sung,J.J.Y.(2015).Gutmucosalmicrobiomeacrossstagesofcolorectalcarcinogenesis.NatureCommunications,6,8727.doi:10.1038/ncomms9727(IF:11.47)
5.Chen,K.,Yang,D.,Li,Xiangchun,Sun,B.,Song,F.,Cao,W.,...Gao,Z.(2015).MutationallandscapeofgastricadenocarcinomainChinese:Implicationsforprognosisandtherapy.ProceedingsoftheNationalAcademyofSciences,6(1),1–6.doi:10.1073/pnas.1422640112(IF:9.674)
6.Song,Y.,Li,L.,Ou,Y.,Gao,Z.,Li,E.,Li,Xiangchun,...Zhan,Q.(2014).Identificationofgenomicalterationsinoesophagealsquamouscellcancer.Nature,509(7498),91–5.doi:10.1038/nature13176(IF:41.456)
7.Yu,J.,Wu,W.K.K.,Li,Xiangchun,X.X.,He,J.,Li,X.-X.X.,Ng,S.S.M.,...Sung,J.J.Y.(2015).Novelrecurrentlymutatedgenesandaprognosticmutationsignatureincolorectalcancer.Gut,64(4),636–45.doi:10.1136/gutjnl-2013-306620(IF:14.66)
8.Song,F.,Li,Xiangchun,Song,F.,Zhao,Y.,&Li,H.(2015).Comparativegenomicanalysisrevealsbilateralbreastcancersaregeneticallyindependent.Oncotarget.doi:10.18632/oncotarget.5569(IF:6.359)
9.Li,C.,Gao,Z.,Li,F.,Li,Xiangchun,Sun,Y.,Wang,M.M.,...Wei,Q.(2015).WholeExomeSequencingIdentifiesFrequentSomaticMutationsinCell-CellAdhesionGenesinChinesePatientswithLungSquamousCellCarcinoma.ScientificReports,5(August),14237.doi:10.1038/srep14237(IF:5.578)
10.Cao,Y.,He,M.,Gao,Z.,Peng,Y.,...Li,Xiangchun,...Ning,G.(2014).ActivatinghotspotL205RmutationinPRKACAandadrenalCushing’ssyndrome.Science,344(6186),913–7.doi:10.1126/science.1249480(IF:33.611)
11.Zhang,L.,Zhou,Y.,Cheng,C.,Cui,H.,Cheng,...Li,Xiangchun,...Cui,Y.(2015).Genomicanalysesrevealmutationalsignaturesandfrequentlyalteredgenesinesophagealsquamouscellcarcinoma.AmericanJournalofHumanGenetics,96(4),597–611.doi:10.1016/j.ajhg.2015.02.017(IF:10.931)
12.Yu,C.,Yu,J.,Yao,X.,Wu,W.K.K.,Lu,Y.,...Li,Xiangchun,...Wang,J.J.(2014).DiscoveryofbiclonaloriginandanoveloncogeneSLC12A5incoloncancerbysingle-cellsequencing.CellResearch,24(6),701–12.doi:10.1038/cr.2014.43(IF:12.413)
13.Zhao,Y.,Yang,J.,Chen,Z.,Gao,Z.,Zhou,F.,Li,Xiangchun,...He,J.(2014).IdentificationofsomaticalterationsinstageIlungadenocarcinomasbynext-generationsequencing.GenesChromosomesandCancer,53(4),289–298.doi:10.1002/gcc.22138(IF:4.041)
14.Xu,L.,Li,X.X.,Cai,M.,Chen,J.,Li,X.X.,Wu,W.K.K.,...Li,Xiangchun,...Yu,J.(2015).IncreasedexpressionofSolutecarrierfamily12member5viageneamplificationcontributestotumourprogressionandmetastasisandassociateswithpoorsurvivalincolorectalcancer.Gut,1–12.doi:10.1136/gutjnl-2014-308257(IF:14.66)
15.Liu,L.,Xu,Y.,He,M.,Zhang,M.,Cui,F.,Lu,L.,...Li,Xiangchun,...Esteban,M.A.(2014).Transcriptionalpausereleaseisarate-limitingstepforsomaticcellreprogramming.CellStemCell,15(5),574–588.doi:10.1016/j.stem.2014.09.018(IF:22.268)
16.Cheng,C.,Zhou,Y.,Li,H.,Xiong,T.,Li,S.,Bi,Y.,...Li,Xiangchun,...Cui,Y.(2016).Whole-GenomeSequencingRevealsDiverseModelsofStructuralVariationsinEsophagealSquamousCellCarcinoma.TheAmericanJournalofHumanGenetics,1–19.doi:10.1016/j.ajhg.2015.12.013(IF:10.931)
17.Tsang,D.P.F.,Wu,W.K.K.,Kang,W.,Lee,Y.-Y.,Wu,F.,Yu,Z.,...Li,Xiangchun,...Cheng,A.S.L.(2016).YinYang1-mediatedepigeneticsilencingoftumour-suppressivemicroRNAsactivatesNuclearFactor-κBinhepatocellularcarcinoma.TheJournalofPathology.doi:10.1002/path.4688(IF:7.429)
18.Tang,S.,Wu,W.K.K.,Li,Xiangchun,Wong,S.H.,Wong,N.,Chan,M.T.V.,...Yu,J.(2016).StratificationofDigestiveCancerswithDifferentPathologicalFeaturesandSurvivalOutcomesbyMicroRNAExpression.ScientificReports,6(4),24466.doi:10.1038/srep24466(IF:5.578)
硕士生导师：张飞
副研究员、硕士研究生导师
2004年毕业于新乡医学院临床医学专业，2007年获得天津医科大学生物化学与分子生物学硕士学位，2013年获得天津医科大学肿瘤学博士学位。2008-2009曾在香港科技大学生物化学系进修。2015年获“天津市创新人才推进计划-青年科技优秀人才”称号，2015年获得天津市优秀博士论文，2016年获得第9届中国肿瘤学术大会优秀论文一等奖，2017年入选天津市“131”创新型人才第二层次，并获得天津医科大学肿瘤医院首批“青年创新人才”称号；发表SCI收录论文15篇，主持国家自然科学基金项目2项，天津市科委课题2项，天津市教委课题1项。
近年来发表SCI论文(*通讯作者)：
4.ZhangF,WangZ,YuanJ,WeiX,TianR,NiuR*:RNAi-mediatedsilencingofAnxa2inhibitsbreastcancercellproliferationbydownregulatingcyclinD1inSTAT3-dependentpathway.BreastCancerResTreat2015,153(2):263-275.
5.ZhangF,WangZ,FanY,XuQ,JiW,TianR,NiuR*:ElevatedSTAT3Signaling-MediatedUpregulationofMMP-2/9ConfersEnhancedInvasionAbilityinMultidrug-ResistantBreastCancerCells.Internationaljournalofmolecularsciences2015,16(10):24772-24790.
6.ZhangF,LiuY,WangZ,SunX,YuanJ,WangT,TianR,JiW,YuM,ZhaoY,NiuR*:AnovelAnxa2-interactingproteinEbp1inhibitscancerproliferationandinvasionbysuppressingAnxa2proteinlevel.MolCellEndocrinol2015,411:75-85.
7.ZhangF,ZhangH,WangZ,YuM,TianR,JiW,YangY,NiuR*:P-glycoproteinassociateswithAnxa2andpromotesinvasioninmultidrugresistantbreastcancercells.BiochemPharmacol2014,87(2):292-302.
8.HanJ,ZhangF,YuM,ZhaoP,JiW,ZhangH,WuB,WangY,NiuR:RNAinterference-mediatedsilencingofNANOGreducescellproliferationandinducesG0/G1cellcyclearrestinbreastcancercells.CancerLett2012,321(1):80-88.
9.ZhangF,ZhangX,LiM,ChenP,ZhangB,GuoH,CaoW,WeiX,CaoX,HaoXetal:mTORcomplexcomponentRictorinteractswithPKCzetaandregulatescancercellmetastasis.CancerRes2010,70(22):9360-9370.
10.ZhangF,ZhangL,ZhangB,WeiX,YangY,QiRZ,YingG,ZhangN,NiuR:Anxa2playsacriticalroleinenhancedinvasivenessofthemultidrugresistanthumanbreastcancercells.JProteomeRes2009,8(11):5041-5047.